Chikungunya Virus Vaccine: What we know so far?

Chikungunya Virus Vaccine : Bharat Biotech International is currently conducting Phase 2/3 trials for its Chikungunya vaccine candidate in Costa Rica. The trials are expect to include patients from Panama and Colombia as well. Meanwhile, Valneva’s vaccine candidate has shown promising results by producing neutralizing antibodies in 98.5% of volunteers. This development is significant in the fight against Chikungunya, a viral disease transmit through mosquito bites that causes symptoms such as fever, joint pain, and rash. With ongoing research and clinical trials, there is hope for an effective vaccine to prevent this debilitating illness in the future. The success of these vaccines can have a significant impact on reducing the transmission of Chikungunya and improving public health outcomes globally.

The Chikungunya virus is a mosquito-borne illness that has been on the rise in recent years, causing widespread outbreaks and leaving many people searching for answers. If you’re concern about protecting yourself and your love ones from this debilitating disease, you may be wondering if there is a Chikungunya virus vaccine available. In this blog post, we’ll explore the current state of vaccine development for Chikungunya and what you can do to protect yourself in the meantime. Don’t let fear of the unknown keep you from taking action – read on to learn more about the potential for a Chikungunya virus vaccine and how it could change the game in preventing this dangerous illness.

Chikungunya Virus Vaccine

What's In the Article

Chikungunya is a viral disease that spreads through mosquito bites and causes symptoms like fever, joint pain, muscle pain, joint swelling, headache, nausea, fatigue, and rash. The name Chikungunya comes from the Makonde language spoken in Tanzania and Mozambique. The most debilitating symptom of Chikungunya is joint pain which can last for weeks or even years. To combat this disease, clinical trials are being conduct across different countries where Chikungunya is endemic such as Guatemala, Costa Rica, Panama, Columbia, Thailand and others. These trials aim to find effective treatments and prevention methods against this virus.

Costa Rica is conducting a Phase 2/3 clinical trial of Bharat Biotech’s BBV87 vaccine candidate, which is fund by CEPI and India Centric Epidemic Preparedness mission. The study aims to assess the safety and immune response of the vaccine candidate in healthy adults. This trial is an important step towards developing a safe and effective vaccine against COVID-19, which has affect millions of people worldwide. It is hope that this vaccine candidate will prove successful in protecting people from the virus and ending the pandemic.

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Chikungunya Virus Vaccine

Chikungunya Virus Vaccine Details

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Chikungunya Disease

Over the past 15 years, Chikungunya, a disease transmitted by mosquitoes, has cause at least 5 million infections and is consider a global health threat. It affects people of all ages and genders, with symptoms including fever, viremia, joint pain, and a rash known as maculopapular rash. Previous studies have shown that more than half of the patients experience long-lasting illness leading to debilitating polyarthritis. The estimate case-fatality ratio ranges from 0.3 to 1 per 1000 cases, with the majority of deaths occurring in older individuals, neonates, and adults with pre-existing medical conditions.

Throughout history, vaccination has been the most successful method of safeguarding populations and eliminating infectious diseases. Recent developments in vaccine strategies for Chikungunya have demonstrate safe immune responses in both animal models and humans. The development of effective vaccines against this debilitating disease is crucial as it continues to spread rapidly across countries and regions. With ongoing research into new vaccine approaches, there is hope that a breakthrough can be made in the fight against Chikungunya and other infectious diseases.

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Vaccination Therapy

Valneva Austria GmbH’s single-dose vaccine, known as Ixchiq, has been authorize for administration to adults who have a higher risk of contracting the virus. Ixchiq has been grant breakthrough therapy status and fast-track treatment designation. Although deaths and severe illnesses are rare, there have been over 5 million cases in the past 15 years. Health experts consider it to be an increasing threat to global health, exacerbate by climate change.

A single dosage of the chikungunya vaccine has been found to produce neutralizing antibodies that protect against illness in 99% of individuals test after twenty-eight days. These antibodies are design to recognize and neutralize the chikungunya virus, which can cause fever, joint pain, and other symptoms. The high level of protection provide by the vaccine is a promising development in the fight against this mosquito-borne disease, which has no specific treatment or cure. However, further research is need to determine the long-term effectiveness of the vaccine and its ability to prevent outbreaks on a larger scale.

Chikungunya Virus Symptoms

Chikungunya fever is an illness cause by the chikungunya virus. The symptoms usually appear between 3 to 7 days after being bitten by an infect mosquito and include a high fever, severe joint pain, muscle pain, headache, swelling of the joints, and rash. While Chikungunya rarely leads to death, its symptoms can be debilitating and last for several months or even years. There is no specific treatment for Chikungunya fever, and prevention is key. It is recommend to avoid mosquito bites by using mosquito nets, wearing protective clothing, and using mosquito repellent.

Although most patients with this condition recover within a week, severe cases can have lasting effects on certain groups of people. Newborns, older adults, and individuals with underlying medical conditions are at a higher risk for complications. Joint pain is a common symptom that can persist even after the initial recovery period. It is important to seek medical attention if you experience any symptoms as early diagnosis and treatment can help prevent further complications.

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Vaccine Test

Valneva is currently conducting phase 3 clinical trials for its VLA1553 chikungunya vaccine. This vaccine is a modified form of the live virus, which may not be suitable for individuals with weaken immune systems or pregnant women. The study involve 4,115 healthy adults from various locations across the Unite States. Among these participants, 75% receive a single dose of VLA1553 inject into their arms, while the remaining individuals were given a placebo.

According to The Lancet’s study, the VLA1553 vaccine was well-tolerate by all age groups with only mild or moderate adverse events reporte, such as headaches, fatigue, muscle or joint pain, and injection site pain. Serious adverse events occurred in a small percentage of participants who receive the VLA1553 vaccine compare to those who receive a placebo. These serious adverse events include mild muscle pain and fever but did not result in any deaths. Overall, the study shows that the VLA1553 vaccine has a good safety profile with few side effects.

Immune Response

In order to safeguard against infections caused by pathogens, both innate and adaptive immunity are necessary. Alphaviruses stimulate the body’s type-I IFN responses, resulting in increase levels of IFN-α in individuals infect with CHIKV. Various antigen-presenting cells such as Langerhans cells, macrophages, and dendritic cells play a role in triggering innate immune responses.

In order to defend against infections caused by pathogens, both innate and adaptive immunity are necessary. Alphaviruses have the ability to trigger type-I IFN responses, resulting in increase levels of IFN-α in patients infect with CHIKV. Antigen-presenting cells such as Langerhans cells, macrophages, and dendritic cells play a role in initiating innate immune responses.

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Consumers Statistics who pay for Vaccine

A total of 496 interviews were carried out, with 23 of them being exclude from the analysis. The majority of participants, specifically 57.3% of them, were female and possess a high school diploma (90.7%). Additionally, the respondents were employ (87.7%) and had private health insurance (62.6%).

The median value for a single-dose vaccination was found to be US$ 31.17 (120.00 BRL) according to the WTP. There was a statistically significant correlation between the WTP and both the presence of private health insurance and the monthly family income.

Chikungunya Virus Vaccination Price

The cost of the Chikungunya vaccine has not been announce yet, but it is anticipate that it will be reveal shortly. This immunization is critical in preventing the spread of the Chikungunya virus, which is transmitted by mosquitoes and can cause significant symptoms like fever and joint pain. It is imperative to stay inform about any developments regarding the vaccine’s pricing to guarantee timely access to this essential preventative measure.

It’s worth noting that while there isn’t a cure for Chikungunya, vaccination is one of the most effective ways to prevent infection. As such, people living in areas where outbreaks are common should consider getting vaccinate as soon as possible. Additionally, taking measures like using mosquito repellent and wearing protective clothing can help reduce your chances of being bitten by infect mosquitoes.

Chikungunya Virus Vaccine FAQ’S

Is there a vaccine for chikungunya?

Ixchiq (Valneva Austria), the first vaccine for chikungunya virus disease (CVD), has recently been granted approval by the Food and Drug Administration. This vaccine is intended for adults who have a higher likelihood of being exposed to CVD. Ixchiq is a single-dose vaccine that contains a weakened, live form of the chikungunya virus (CHIKV).

What is the injection for chikungunya?

Individuals who are susceptible to contracting chikungunya and fall into the adult age group may opt to receive a vaccine. The U.S. Food and Drug Administration has granted approval for one particular vaccine, which involves administering a single dose of an injected weakened form of the chikungunya virus.

Who discovered chikungunya vaccine?

The FDA has approved Valneva's chikungunya virus vaccine Ixchiq for adults at risk of exposure to the virus. The company will focus on selling the first-in-class vaccine to US travellers heading to countries in the tropics and subtropics where the disease is endemic.

What is the new mosquito virus vaccine?

In NSW, a free Japanese encephalitis virus vaccination is available for people aged 2 months or older who live or routinely work in any of the below Local Government Areas and: regularly spend time outdoors placing them at risk of mosquito bites, or. are experiencing homelessness.

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